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Characteristic	Details
Generic Name	Prednisolone
Dosage Forms	Tablets, Syrup, Injection
Strengths	5mg, 10mg, 20mg
Drug Class	Corticosteroid
Primary Uses	Inflammation, Allergies, Asthma
Learn More About Prednisolone

Chemical Structure

The molecular formula of Prednisolone is C21H28O5. It belongs to the corticosteroid class. The compound features a cyclopentanoperhydrophenanthrene structure. The synthetic glucocorticoid is a derivative of cortisone. This enhances its anti-inflammatory efficacy. The steroid is characterized by a hydroxyl group at the 11β position. It alters the structure, distinguishing it from other corticosteroids.

The hydroxyl configuration increases its solubility. This plays a crucial role in its pharmacokinetic properties. The presence of double bonds in the A-ring influences its biological activity. This specific configuration facilitates the drug’s binding to glucocorticoid receptors. The molecular weight is approximately 360.45 g/mol. Prednisolone exhibits high binding affinity to plasma proteins, crucial for its systemic effects.

Dosage Information

Prednisolone 20mg is a standard dosage for severe conditions. Dosage varies based on disease severity. The initial dose often ranges from 5mg to 60mg per day. Dosing may be tapered or adjusted depending on therapeutic response. In chronic conditions, long-term low dosing might be necessary. Prednisolone tablets are available in 5mg, 10mg, and 20mg strengths.

The oral route remains most common. For rapid effect, intravenous administration might be used. Dosage regimen must be individualized. Physician supervision is necessary for dose adjustments. Sudden cessation should be avoided. Gradual dose reduction is critical to prevent adrenal insufficiency.

Indications

Prednisolone is indicated for various inflammatory and autoimmune disorders. It treats rheumatoid arthritis, asthma, and lupus. Allergic reactions and certain cancers also warrant its use. It manages acute exacerbations in chronic diseases. Eye inflammation, skin conditions, and ulcerative colitis respond well to treatment.

Its immune suppression capabilities aid in transplant rejection management. Prednisolone reduces inflammation by inhibiting pro-inflammatory cytokines. It stabilizes cellular membranes and reduces permeability. This alleviates symptoms and improves quality of life for patients.

Cautions with Other Medicines

Drug interactions may occur with Prednisolone. Careful consideration is necessary when co-administering with NSAIDs. The combination increases gastrointestinal bleed risk. Warfarin use requires monitoring, as Prednisolone can alter anticoagulant effects. Diabetic patients should note that it may elevate blood sugar levels.

Concurrent use with vaccines may reduce immunogenicity.
Combining with diuretics could cause hypokalemia.
Rifampin may decrease Prednisolone efficacy.

Regular liver function tests are advised. Enzyme inducers and inhibitors necessitate dose modification. Physician guidance ensures safe polypharmacy management.

Prednisolone Side Effects

Common side effects include weight gain and fluid retention. Long-term use may result in osteoporosis. Patients report mood swings and insomnia. High doses may induce hypertension. Immune suppression increases infection susceptibility.

Gastrointestinal upset is frequently observed. Cushing’s syndrome can occur with prolonged exposure. Eye complications, like cataracts, are possible. Skin thinning and bruising are additional risks. Frequent monitoring mitigates adverse outcomes.

Purchasing Prednisolone Without a Prescription

Buying Prednisolone without a prescription poses risks. Self-medication leads to potential misuse. Adverse effects may go unmonitored. Accurate dosing requires medical expertise. Pharmacist consultation is advised before usage.

Quality control is questionable with unauthorized sources. The risk of counterfeit medication exists. Legal implications vary by region. Prescription ensures accountability and professional oversight. Trusted healthcare providers offer the best advice on Prednisolone use.

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